Maria Josepha Anna (Angelica) Klausmann (née Uhrig) was born in Laudenbach on the Main, Germany.  She was the brother of Franz Ignatz Uhrig, an early St. Louis, Missouri Brewer.  In 1841 she married Carl Klausmann, who, during the next decade, opened his own brewery in St. Louis.  

When Carl died in 1859, Angelica took over the family business and, despite being a single mother with five children, ran the firm for nearly two decades.  In 1873, she expanded the brewery, and in 1878, incorporated it with investors Nicholas Eckerle, John Krauss, and Fred Rathgeber.

Maria Josepha Anna Klausmann died on April 10, 1898.  Despite her lifetime of charitable work, she left an estate worth over $200,000.  Her final words were, "Remember the poor."